Dataset Information

Intake and serum concentrations of ?-tocopherol in relation to fractures in elderly women and men: 2 cohort studies.

ABSTRACT:

Background

A reduction in the formation of free radicals and oxidative stress might reduce the rate of bone loss and muscle wasting.

Objective

The objective was to determine whether ?-tocopherol intake or serum concentrations are associated with fracture risk in older women and men.

Design

Two cohort studies, the Swedish Mammography Cohort (SMC; n = 61,433 women) and the Uppsala Longitudinal Study of Adult Men (ULSAM; n = 1138 men), were used.

Results

During 19 y of follow-up, 14,738 women in the SMC experienced a first fracture at any site (3871 hip fractures). A higher hip fracture rate was observed with lower intakes of ?-tocopherol. Compared with the highest quintile of intake, the lowest quintile had a multivariable-adjusted HR of 1.86 (95% CI: 1.67, 2.06). The HR of any fracture was 1.20 (95% CI: 1.14, 1.28). ?-Tocopherol-containing supplement use was associated with a reduced rate of hip fracture (HR: 0.78; 95% CI: 0.65, 0.93) and any fracture (HR: 0.86; 95% CI: 0.78, 0.94). Compared with the highest quintile of ?-tocopherol intake in ULSAM (follow-up: 12 y), lower intakes (quintiles 1-4) were associated with a higher rate of hip fracture (HR: 3.33; 95% CI: 1.43, 7.76) and any fracture (HR: 1.84; 95% CI: 1.18, 2.88). The HR for hip fracture in men for each 1-SD decrease in serum ?-tocopherol was 1.58 (95% CI: 1.13, 2.22) and for any fracture was 1.23 (95% CI: 1.02, 1.48).

Conclusion

Low intakes and low serum concentrations of ?-tocopherol are associated with an increased rate of fracture in elderly women and men.

SUBMITTER: Michaelsson K

PROVIDER: S-EPMC3862449 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature

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Publications

Intake and serum concentrations of α-tocopherol in relation to fractures in elderly women and men: 2 cohort studies.

Michaëlsson Karl K Wolk Alicja A Byberg Liisa L Ärnlöv Johan J Melhus Håkan H

The American journal of clinical nutrition 20131113 1

<h4>Background</h4>A reduction in the formation of free radicals and oxidative stress might reduce the rate of bone loss and muscle wasting.<h4>Objective</h4>The objective was to determine whether α-tocopherol intake or serum concentrations are associated with fracture risk in older women and men.<h4>Design</h4>Two cohort studies, the Swedish Mammography Cohort (SMC; n = 61,433 women) and the Uppsala Longitudinal Study of Adult Men (ULSAM; n = 1138 men), were used.<h4>Results</h4>During 19 y of ...[more]

PMID: 24225359

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