Ontology highlight
ABSTRACT:
SUBMITTER: Brandenburg B
PROVIDER: S-EPMC3862845 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
PloS one 20131211 12
Human monoclonal antibodies have been identified which neutralize broad spectra of influenza A or B viruses. Here, we dissect the mechanisms by which such antibodies interfere with infectivity. We distinguish four mechanisms that link the conserved hemagglutinin (HA) epitopes of broadly neutralizing antibodies to critical processes in the viral life cycle. HA-stem binding antibodies can act intracellularly by blocking fusion between the viral and endosomal membranes and extracellularly by preven ...[more]