Ontology highlight
ABSTRACT:
SUBMITTER: de Vries E
PROVIDER: S-EPMC7172302 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
de Vries Erik E Du Wenjuan W Guo Hongbo H de Haan Cornelis A M CAM
Trends in microbiology 20191017 1
Influenza A viruses (IAVs) occasionally cross the species barrier and adapt to novel host species. This requires readjustment of the functional balance of the sialic acid receptor-binding hemagglutinin (HA) and the receptor-destroying neuraminidase (NA) to the sialoglycan-receptor repertoire of the new host. Novel techniques have revealed mechanistic details of this HA-NA-receptor balance, emphasizing a previously underappreciated crucial role for NA in driving the motility of receptor-associate ...[more]