Ontology highlight
ABSTRACT:
SUBMITTER: Gorden A
PROVIDER: S-EPMC3864002 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Gorden Alexis A Yang Rongze R Yerges-Armstrong Laura M LM Ryan Kathleen A KA Speliotes Elizabeth E Borecki Ingrid B IB Harris Tamara B TB Chu Xin X Wood G Craig GC Still Christopher D CD Shuldiner Alan R AR Gerhard Glenn S GS
Human heredity 20130410 1
<h4>Objective</h4>Obesity-associated non-alcoholic fatty liver disease (NAFLD) may cause liver dysfunction and failure. In a previously reported genome-wide association meta-analysis, single nucleotide polymorphisms (SNPs) near PNPLA3, NCAN, GCKR, LYPLAL1 and PPP1R3B were associated with NAFLD and with distinctive serum lipid profiles. The present study examined the relevance of these variants to NAFLD in extreme obesity.<h4>Methods</h4>In 1,092 bariatric surgery patients, the candidate SNPs wer ...[more]