Ontology highlight
ABSTRACT:
SUBMITTER: Jones JL
PROVIDER: S-EPMC3864306 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Jones Joanne L JL Thompson Sara A J SA Loh Priscilla P Davies Jessica L JL Tuohy Orla C OC Curry Allison J AJ Azzopardi Laura L Hill-Cawthorne Grant G Fahey Michael T MT Compston Alastair A Coles Alasdair J AJ
Proceedings of the National Academy of Sciences of the United States of America 20131126 50
The association between lymphopenia and autoimmunity is recognized, but the underlying mechanisms are poorly understood and have not been studied systematically in humans. People with multiple sclerosis treated with the lymphocyte-depleting monoclonal antibody alemtuzumab offer a unique opportunity to study this phenomenon; one in three people develops clinical autoimmunity, and one in three people develops asymptomatic autoantibodies after treatment. Here, we show that T-cell recovery after ale ...[more]