Ontology highlight
ABSTRACT:
SUBMITTER: Vignali D
PROVIDER: S-EPMC4794519 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Vignali Debora D Monti Paolo P
Current diabetes reports 20160501 5
Immunomodulation of the autoreactive T cell response is considered a major strategy to control beta-cell autoimmunity, both in the natural history of type 1 diabetes and in islet transplantation, which can be affected by autoimmunity recurrence. So far, these strategies have had modest results, prompting efforts to define novel cellular and molecular targets to control autoreactive T cell expansion and activation. Novel findings highlighted the important role of the homeostatic cytokine interleu ...[more]