Ontology highlight
ABSTRACT:
SUBMITTER: Ibarrondo FJ
PROVIDER: S-EPMC3865278 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Mucosal immunology 20121114 3
Chronic inappropriate immune activation is the central defect-driving loss of CD4(+) T helper cells and progression to AIDS in persons with HIV-1 infection, but the mechanisms remain controversial. We examined key regulatory invariant receptor natural killer T (iNKT) cells in the gut, the largest reservoir of lymphocytes and a key arena of HIV-1 pathogenesis. In healthy control persons, the anti-inflammatory CD4(+) iNKT-cell subset predominated over the pro-inflammatory CD4(-) iNKT-cell subset i ...[more]