Ontology highlight
ABSTRACT:
SUBMITTER: Abrami L
PROVIDER: S-EPMC3866279 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Abrami Laurence L Brandi Lucia L Moayeri Mahtab M Brown Michael J MJ Krantz Bryan A BA Leppla Stephen H SH van der Goot F Gisou FG
Cell reports 20131114 4
Anthrax lethal toxin is a classical AB toxin comprised of two components: protective antigen (PA) and lethal factor (LF). Here, we show that following assembly and endocytosis, PA forms a channel that translocates LF, not only into the cytosol, but also into the lumen of endosomal intraluminal vesicles (ILVs). These ILVs can fuse and release LF into the cytosol, where LF can proteolyze and disable host targets. We find that LF can persist in ILVs for days, fully sheltered from proteolytic degrad ...[more]