Ontology highlight
ABSTRACT:
SUBMITTER: Antonellis PJ
PROVIDER: S-EPMC3866489 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Antonellis Patrick J PJ Pollock Lana M LM Chou Shih-Wei SW Hassan Ahmed A Geng Ruishuang R Chen Xi X Fuchs Elaine E Alagramam Kumar N KN Auer Manfred M McDermott Brian M BM
The Journal of neuroscience : the official journal of the Society for Neuroscience 20140101 1
The precise morphology of the mechanosensitive hair bundle requires seamless integration of actin and microtubule networks. Here, we identify Acf7a (actin crosslinking family protein 7a) as a protein positioned to bridge these distinct cytoskeletal networks in hair cells. By imaging Acf7a-Citrine fusion protein in zebrafish and immunolabeling of vestibular and cochlear mouse hair cells, we show that Acf7a and ACF7 circumscribe, underlie, and are interwoven into the cuticular plate (CP), and they ...[more]