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A chemical perspective on transcriptional fidelity: dominant contributions of sugar integrity revealed by unlocked nucleic acids.

ABSTRACT: Transcription unlocked: A synthetic chemical biology approach involving unlocked nucleic acids was used to dissect the contribution of sugar backbone integrity to the RNA Polymerase?II (Pol?II) transcription process. An unexpected dominant role for sugar-ring integrity in Pol?II transcriptional efficiency and fidelity was revealed.

SUBMITTER: Xu L

PROVIDER: S-EPMC3866818 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature

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A chemical perspective on transcriptional fidelity: dominant contributions of sugar integrity revealed by unlocked nucleic acids.

Xu Liang L Plouffe Steven W SW Chong Jenny J Wengel Jesper J Wang Dong D

Angewandte Chemie (International ed. in English) 20131024 47

Transcription unlocked: A synthetic chemical biology approach involving unlocked nucleic acids was used to dissect the contribution of sugar backbone integrity to the RNA Polymerase II (Pol II) transcription process. An unexpected dominant role for sugar-ring integrity in Pol II transcriptional efficiency and fidelity was revealed. ...[more]

PMID: 24167045

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