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Oral contrast enhances the resolution of in-life NIS reporter gene imaging.

ABSTRACT: Sodium iodide symporter (NIS) reporter gene imaging is an excellent technology for noninvasive cell fate determination in living animals unless the NIS-transduced cells reside in perigastric organs such as the spleen, liver, diaphragm, omentum, pancreas, perigastric lymph nodes or perigastric tumor deposits. Here we report that orally administered barium sulfate enhances CT definition of the stomach, masks background gamma ray emissions from the stomach and enhances signal detection from radiotracer uptake in NIS-transduced organs.

SUBMITTER: Suksanpaisan L

PROVIDER: S-EPMC3867790 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature

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Oral contrast enhances the resolution of in-life NIS reporter gene imaging.

Suksanpaisan L L Pham L L McIvor S S Russell S J SJ Peng K-W KW

Cancer gene therapy 20130913 11

Sodium iodide symporter (NIS) reporter gene imaging is an excellent technology for noninvasive cell fate determination in living animals unless the NIS-transduced cells reside in perigastric organs such as the spleen, liver, diaphragm, omentum, pancreas, perigastric lymph nodes or perigastric tumor deposits. Here we report that orally administered barium sulfate enhances CT definition of the stomach, masks background gamma ray emissions from the stomach and enhances signal detection from radiotr ...[more]

PMID: 24030210

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