Cross-talk between KLF4 and STAT3 regulates axon regeneration.
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ABSTRACT:
SUBMITTER: Qin S
PROVIDER: S-EPMC3867821 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Publications
Cross-talk between KLF4 and STAT3 regulates axon regeneration.
Qin Song S Zou Yuhua Y Zhang Chun-Li CL
Nature communications 20130101
Cytokine-induced activation of signal transducer and activator of transcription 3 (STAT3) promotes the regrowth of damaged axons in the adult central nervous system (CNS). Here we show that KLF4 physically interacts with STAT3 upon cytokine-induced phosphorylation of tyrosine 705 (Y705) on STAT3. This interaction suppresses STAT3-dependent gene expression by blocking its DNA-binding activity. The deletion of KLF4 in vivo induces axon regeneration of adult retinal ganglion cells (RGCs) via Janus ...[more]
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