Ontology highlight
ABSTRACT:
SUBMITTER: Lin Y
PROVIDER: S-EPMC7425490 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Lin Ye Y Jin Haosheng H Wu Xianqiu X Jian Zhixiang Z Zou Xiongfeng X Huang Jianfeng J Guan Renguo R Wei Xiangling X
Aging 20200727 14
<h4>Objective</h4>To investigate the function of discoidin domain receptor 1 (DDR1) in hepatocellular carcinoma (HCC) and to further clarify the underlying mechanism.<h4>Results</h4>DDR1 was significantly increased in HCC tissues and cells, which was related to clinical staging and prognosis of HCC. Upregulation of DDR1 promoted EMT and glutamine metabolism in HCC cells, while loss of DDR1 showed the opposite effects. STAT3 bound with the promoter of DDR1, and facilitated the phosphorylation of ...[more]