Ontology highlight
ABSTRACT:
SUBMITTER: von Maltzahn J
PROVIDER: S-EPMC3868162 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
von Maltzahn Julia J Zinoviev Radoslav R Chang Natasha C NC Bentzinger C Florian CF Rudnicki Michael A MA
Nature communications 20130101
Wnt signaling has essential roles during embryonic development and tissue homoeostasis. Wnt proteins are post-translationally modified and the attachment of a palmitate moiety at two conserved residues is believed to be a prerequisite for the secretion and function of Wnt proteins. Here we demonstrate that a mammalian Wnt protein can be fully functional without palmitoylation. We generate a truncated Wnt7a variant, consisting of the C-terminal 137 amino acids lacking the conserved palmitoylation ...[more]