Ontology highlight
ABSTRACT:
SUBMITTER: Barupal DK
PROVIDER: S-EPMC3868466 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Barupal Dinesh Kumar DK Lee Sang Jun SJ Karoly Edward D ED Adhya Sankar S
PloS one 20131205 12
The metabolic network in E. coli can be severely affected by the inactivation of metabolic genes that are required to catabolize a nutrient (D-galactose). We hypothesized that the resulting accumulation of small molecules can yield local as well as systemic effects on the metabolic network. Analysis of metabolomics data in wild-type and D-galactose non-utilizing mutants, galT, galU and galE, reveal the large metabolic differences between the wild-type and the mutants when the strains were grown ...[more]