Ontology highlight
ABSTRACT:
SUBMITTER: Schmidt B
PROVIDER: S-EPMC3869341 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Beilstein journal of organic chemistry 20131118
Starting from the conveniently available ex-chiral pool building block (R,R)-hexa-1,5-diene-3,4-diol, the ten-membered ring lactones stagonolide E and curvulide A were synthesized using a bidirectional olefin-metathesis functionalization of the terminal double bonds. Key steps are (i) a site-selective cross metathesis, (ii) a highly diastereoselective extended tethered RCM to furnish a (Z,E)-configured dienyl carboxylic acid and (iii) a Ru-lipase-catalyzed dynamic kinetic resolution to establish ...[more]