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Cycloartanes from Euphorbia aellenii Rech. f. and their Antiproliferative Activity.

ABSTRACT: The cytotoxic chloroform fraction of Euphorbia aellenii afforded two cycloartane type triterpenes-cycloart-25-en-3?,24-diol (1) and 24-methylene-cycloartan-3?-ol (2)-for the first time from this plant. Preparation of cycloartane derivatives, 3?, 24-O-diacetyl-cycloart-25-en as compound 3 and 3?-O-acetyl-24-methylene-cycloartan (4) were conducted by acetylating of 1 and 2, respectively. The structures of the isolated compounds were elucidated by spectroscopic methods and their activities evaluated by proliferation assay on human peripheral blood lymphocytes (PBLs). Comparing the results suggested that anti-proliferation effect of these compounds on PBLs might be due to the presence of free 3-OH group while masking the free OH groups by acetylation, could induce proliferation activity.

SUBMITTER: Ayatollahi AM

PROVIDER: S-EPMC3869593 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature

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Cycloartanes from Euphorbia aellenii Rech. f. and their Antiproliferative Activity.

Ayatollahi Abdul Majid AM Ghanadian Mustafa M Afsharypuor Suleiman S Mesaik M Ahmad MA Abdalla Omer Mohamed OM Shahlaei Mohsen M Farzandi Gholamhossein G Mostafavi Hamid H

Iranian journal of pharmaceutical research : IJPR 20110101 1

The cytotoxic chloroform fraction of Euphorbia aellenii afforded two cycloartane type triterpenes-cycloart-25-en-3β,24-diol (1) and 24-methylene-cycloartan-3β-ol (2)-for the first time from this plant. Preparation of cycloartane derivatives, 3β, 24-O-diacetyl-cycloart-25-en as compound 3 and 3β-O-acetyl-24-methylene-cycloartan (4) were conducted by acetylating of 1 and 2, respectively. The structures of the isolated compounds were elucidated by spectroscopic methods and their activities evaluate ...[more]

PMID: 24363688

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Dataset Information

Cycloartanes from Euphorbia aellenii Rech. f. and their Antiproliferative Activity.

Publications

Cycloartanes from Euphorbia aellenii Rech. f. and their Antiproliferative Activity.

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