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Euphosantianane A?D: Antiproliferative Premyrsinane Diterpenoids from the Endemic Egyptian Plant Euphorbia Sanctae-Catharinae.

ABSTRACT: Euphorbia species are rich in diterpenes. A solvent extraction of Euphorbia sanctae-catharinae, a species indigenous to the Southern Sinai of Egypt, afforded several premyrsinane diterpenoids (1?4) as well as previously reported metabolites (5?13) that included three flavonoids. Isolated compounds were chemically characterized by spectroscopic analysis. Identified compounds were bioassayed for anti-proliferative activity in vitro against colon (Caco-2) and lung (A549) tumor cell lines. Compound 9 exhibited robust anti-proliferative activity against A549 cells (IC50 = 3.3 µM). Absolute configurations for 8 versus 9 were determined by experimental and TDDFT-calculated electronic circular dichorism (ECD) spectra.

SUBMITTER: Hegazy MF 

PROVIDER: S-EPMC6225227 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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Euphosantianane A⁻D: Antiproliferative Premyrsinane Diterpenoids from the Endemic Egyptian Plant <i>Euphorbia Sanctae-Catharinae</i>.

Hegazy Mohamed-Elamir F MF   Hamed Ahmed R AR   Ibrahim Mahmoud A A MAA   Talat Zienab Z   Reda Eman H EH   Abdel-Azim Nahla S NS   Abdel-Azim Nahla S NS   Hammouda Faiza M FM   Nakamura Seikou S   Matsuda Hisashi H   Haggag Eman G EG   Paré Paul W PW   Efferth Thomas T  

Molecules (Basel, Switzerland) 20180901 9

<i>Euphorbia</i> species are rich in diterpenes. A solvent extraction of <i>Euphorbia sanctae-catharinae</i>, a species indigenous to the Southern Sinai of Egypt, afforded several premyrsinane diterpenoids (<b>1</b>⁻<b>4</b>) as well as previously reported metabolites (<b>5</b>⁻<b>13</b>) that included three flavonoids. Isolated compounds were chemically characterized by spectroscopic analysis. Identified compounds were bioassayed for anti-proliferative activity in vitro against colon (Caco-2) a  ...[more]

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