Novel harmful recessive haplotypes identified for fertility traits in Nordic Holstein cattle.
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ABSTRACT:
SUBMITTER: Sahana G
PROVIDER: S-EPMC3869739 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Publications
Novel harmful recessive haplotypes identified for fertility traits in Nordic Holstein cattle.
Sahana Goutam G Nielsen Ulrik Sander US Aamand Gert Pedersen GP Lund Mogens Sandø MS Guldbrandtsen Bernt B
PloS one 20131220 12
Using genomic data, lethal recessives may be discovered from haplotypes that are common in the population but never occur in the homozygote state in live animals. This approach only requires genotype data from phenotypically normal (i.e. live) individuals and not from the affected embryos that die. A total of 7,937 Nordic Holstein animals were genotyped with BovineSNP50 BeadChip and haplotypes including 25 consecutive markers were constructed and tested for absence of homozygotes states. We have ...[more]
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