Ontology highlight
ABSTRACT:
SUBMITTER: Keng Yoon Y
PROVIDER: S-EPMC3870127 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Keng Yoon Yeong Y Ashraf Ali Mohamed M Choon Tan Soo TS Ismail Rusli R Chee Wei Ang A Suresh Kumar Raju R Osman Hasnah H Beevi Farzana F
BioMed research international 20131205
A total of seven novel benzimidazoles were synthesized by a 4-step reaction starting from 4-fluoro-3-nitrobenzoic acid under relatively mild reaction conditions. The synthesized compounds were screened for their antimycobacterial activity against M. tuberculosis H₃₇Rv (MTB-H₃₇Rv) and INH-resistant M. tuberculosis (INHR-MTB) strains using agar dilution method. Three of them displayed good activity with MIC of less than 0.2 μM. Compound ethyl 1-(2-(4-(4-(ethoxycarbonyl)-2-aminophenyl)piperazin-1-y ...[more]