Ontology highlight
ABSTRACT:
SUBMITTER: Koyanagi-Aoi M
PROVIDER: S-EPMC3870695 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Koyanagi-Aoi Michiyo M Ohnuki Mari M Takahashi Kazutoshi K Okita Keisuke K Noma Hisashi H Sawamura Yuka Y Teramoto Ito I Narita Megumi M Sato Yoshiko Y Ichisaka Tomoko T Amano Naoki N Watanabe Akira A Morizane Asuka A Yamada Yasuhiro Y Sato Tosiya T Takahashi Jun J Yamanaka Shinya S
Proceedings of the National Academy of Sciences of the United States of America 20131120 51
We examined the gene expression and DNA methylation of 49 human induced pluripotent stem cells (hiPSCs) and 10 human embryonic stem cells and found overlapped variations in gene expression and DNA methylation in the two types of human pluripotent stem cell lines. Comparisons of the in vitro neural differentiation of 40 hiPSCs and 10 human embryonic stem cells showed that seven hiPSC clones retained a significant number of undifferentiated cells even after neural differentiation culture and forme ...[more]