Ontology highlight
ABSTRACT:
SUBMITTER: Lachmann N
PROVIDER: S-EPMC4325194 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Lachmann Nico N Ackermann Mania M Frenzel Eileen E Liebhaber Steffi S Brennig Sebastian S Happle Christine C Hoffmann Dirk D Klimenkova Olga O Lüttge Doreen D Buchegger Theresa T Kühnel Mark Philipp MP Schambach Axel A Janciauskiene Sabina S Figueiredo Constanca C Hansen Gesine G Skokowa Julia J Moritz Thomas T
Stem cell reports 20150201 2
Interleukin-3 (IL-3) is capable of supporting the proliferation of a broad range of hematopoietic cell types, whereas granulocyte colony-stimulating factor (G-CSF) and macrophage CSF (M-CSF) represent critical cytokines in myeloid differentiation. When this was investigated in a pluripotent-stem-cell-based hematopoietic differentiation model, IL-3/G-CSF or IL-3/M-CSF exposure resulted in the continuous generation of myeloid cells from an intermediate myeloid-cell-forming complex containing CD34( ...[more]