Ontology highlight
ABSTRACT:
SUBMITTER: Yanai H
PROVIDER: S-EPMC3870753 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Yanai Hideyuki H Matsuda Atsushi A An Jianbo J Koshiba Ryuji R Nishio Junko J Negishi Hideo H Ikushima Hiroaki H Onoe Takashi T Ohdan Hideki H Yoshida Nobuaki N Taniguchi Tadatsugu T
Proceedings of the National Academy of Sciences of the United States of America 20131203 51
High-mobility group box 1 (HMGB1) is a DNA-binding protein abundantly expressed in the nucleus that has gained much attention for its regulation of immunity and inflammation. Despite this, whether and how HMGB1 contributes to protective and/or pathological responses in vivo is unclear. In this study, we constructed Hmgb1-floxed (Hmgb1(f)(/f)) mice to achieve the conditional inactivation of the gene in a cell- and tissue-specific manner by crossing these mice with an appropriate Cre recombinase t ...[more]