Ontology highlight
ABSTRACT:
SUBMITTER: Lamkanfi M
PROVIDER: S-EPMC3428148 | biostudies-other | 2010 Oct
REPOSITORIES: biostudies-other
Lamkanfi Mohamed M Sarkar Anasuya A Vande Walle Lieselotte L Vitari Alberto C AC Amer Amal O AO Wewers Mark D MD Tracey Kevin J KJ Kanneganti Thirumala-Devi TD Dixit Vishva M VM
Journal of immunology (Baltimore, Md. : 1950) 20100827 7
Endotoxin administration recapitulates many of the host responses to sepsis. Inhibitors of the cysteine protease caspase 1 have long been sought as a therapeutic because mice lacking caspase 1 are resistant to LPS-induced endotoxic shock. According to current thinking, caspase 1-mediated shock requires the proinflammatory caspase 1 substrates IL-1β and IL-18. We show, however, that mice lacking both IL-1β and IL-18 are normally susceptible to LPS-induced splenocyte apoptosis and endotoxic shock. ...[more]