Ontology highlight
ABSTRACT:
SUBMITTER: Villegas SN
PROVIDER: S-EPMC3871052 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Villegas S Nahuel SN Rothová Michaela M Barrios-Llerena Martin E ME Pulina Maria M Hadjantonakis Anna-Katerina AK Le Bihan Thierry T Astrof Sophie S Brickman Joshua M JM
eLife 20131224
During embryonic development signalling pathways act repeatedly in different contexts to pattern the emerging germ layers. Understanding how these different responses are regulated is a central question for developmental biology. In this study, we used mouse embryonic stem cell (mESC) differentiation to uncover a new mechanism for PI3K signalling that is required for endoderm specification. We found that PI3K signalling promotes the transition from naïve endoderm precursors into committed anteri ...[more]