Ontology highlight
ABSTRACT:
SUBMITTER: Kumar S
PROVIDER: S-EPMC3871207 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Kumar Sarvesh S Painter Thomas O TO Pal Benoy K BK Neuenswander Benjamin B Malinakova Helena C HC
ACS combinatorial science 20110720 5
Parallel solution-phase synthesis of combinatorial libraries of dihydroindenoisoquinolines employing a sequential Cu(I)/Pd(0)-catalyzed multicomponent coupling and annulation protocol was realized. The scope and limitations of the protocol with respect to the substitution pattern in the aryl ring of the indene core, as well as the N-substituent have been defined, revealing that the methodology is compatible with a wide-range of aliphatic linear, branched, and ester functionalized N-substituents. ...[more]