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Sequential Cu(I)/Pd(0)-catalyzed multicomponent coupling and annulation protocol for the synthesis of indenoisoquinolines.

ABSTRACT: Copper-catalyzed coupling of imines, vinylstannanes, or alkynes and o-bromoaroyl chlorides followed by Pd(0)-catalyzed annulations afforded indenoisoquinolines. Protocols requiring minimal purifications were developed, providing new methods for the construction of combinatorial libraries.

SUBMITTER: Jayanth TT

PROVIDER: S-EPMC3871195 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature

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Sequential Cu(I)/Pd(0)-catalyzed multicomponent coupling and annulation protocol for the synthesis of indenoisoquinolines.

Jayanth Thiruvellore Thatai TT Zhang Lei L Johnson Thomas S TS Malinakova Helena C HC

Organic letters 20090201 4

Copper-catalyzed coupling of imines, vinylstannanes, or alkynes and o-bromoaroyl chlorides followed by Pd(0)-catalyzed annulations afforded indenoisoquinolines. Protocols requiring minimal purifications were developed, providing new methods for the construction of combinatorial libraries. ...[more]

PMID: 19159326

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