Ontology highlight
ABSTRACT:
SUBMITTER: Montresor A
PROVIDER: S-EPMC3871442 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Montresor Alessio A Bolomini-Vittori Matteo M Toffali Lara L Rossi Barbara B Constantin Gabriela G Laudanna Carlo C
The Journal of cell biology 20131201 6
Lymphocyte recruitment is regulated by signaling modules based on the activity of Rho and Rap small guanosine triphosphatases that control integrin activation by chemokines. We show that Janus kinase (JAK) protein tyrosine kinases control chemokine-induced LFA-1- and VLA-4-mediated adhesion as well as human T lymphocyte homing to secondary lymphoid organs. JAK2 and JAK3 isoforms, but not JAK1, mediate CXCL12-induced LFA-1 triggering to a high affinity state. Signal transduction analysis showed t ...[more]