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Relationship between HbA1c and continuous glucose monitoring in Chinese population: a multicenter study.


ABSTRACT:

Objective

Since there is a paucity of reference data in the literature to indicate the relationship between HbA1c, and 24 h mean blood glucose (MBG) from continuous glucose monitoring (CGM) in Chinese populations, we described the above relationship in adult Chinese subjects with different glucose tolerance status.

Methods

Seven-hundred-and-forty-two individuals without history of diabetes were included to the study at 11 hospitals in urban areas across China from 2007-2009 and data of 673 subjects were included into the final analysis. Oral glucose tolerance test (OGTT) classified the participants as nondiabetic subjects, including those with normal glucose regulation (NGR; n?=?121) and impaired glucose regulation (IGR; n?=?209), or newly diagnosed type 2 diabetes (n?=?343). All participants completed testing for HbA1c levels and wore a CGM system for three consecutive days. The 24 h MBG levels were calculated. Spearman correlations and linear regression analyses were applied to quantify the relationship between glucose markers.

Results

The levels of HbA1c and 24 h MBG significantly increased with presence of glucose intolerance (NGRConclusionsOur study provided the reference data of the relationship between HbA1c and CGM in Chinese subjects.

SUBMITTER: Zhou J 

PROVIDER: S-EPMC3871656 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Publications

Relationship between HbA1c and continuous glucose monitoring in Chinese population: a multicenter study.

Zhou Jian J   Mo Yifei Y   Li Hong H   Ran Xingwu X   Yang Wenying W   Li Qiang Q   Peng Yongde Y   Li Yanbing Y   Gao Xin X   Luan Xiaojun X   Wang Weiqing W   Xie Yun Y   Jia Weiping W  

PloS one 20131223 12


<h4>Objective</h4>Since there is a paucity of reference data in the literature to indicate the relationship between HbA1c, and 24 h mean blood glucose (MBG) from continuous glucose monitoring (CGM) in Chinese populations, we described the above relationship in adult Chinese subjects with different glucose tolerance status.<h4>Methods</h4>Seven-hundred-and-forty-two individuals without history of diabetes were included to the study at 11 hospitals in urban areas across China from 2007-2009 and da  ...[more]

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