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Flow-mediated stem cell labeling with superparamagnetic iron oxide nanoparticle clusters.


ABSTRACT: This study presents a strategy to enhance the uptake of superparamagnetic iron oxide nanoparticle (SPIO) clusters by manipulating the cellular mechanical environment. Specifically, stem cells exposed to an orbital flow ingested almost a 2-fold greater amount of SPIO clusters than those cultured statically. Improvements in magnetic resonance (MR) contrast were subsequently achieved for labeled cells in collagen gels and a mouse model. Overall, this strategy will serve to improve the efficiency of cell tracking and therapies.

SUBMITTER: Clay N 

PROVIDER: S-EPMC3872536 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature

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Flow-mediated stem cell labeling with superparamagnetic iron oxide nanoparticle clusters.

Clay Nicholas N   Baek Kwanghyun K   Shkumatov Artem A   Lai Mei-Hsiu MH   Smith Cartney E CE   Rich Max M   Kong Hyunjoon H  

ACS applied materials & interfaces 20131001 20


This study presents a strategy to enhance the uptake of superparamagnetic iron oxide nanoparticle (SPIO) clusters by manipulating the cellular mechanical environment. Specifically, stem cells exposed to an orbital flow ingested almost a 2-fold greater amount of SPIO clusters than those cultured statically. Improvements in magnetic resonance (MR) contrast were subsequently achieved for labeled cells in collagen gels and a mouse model. Overall, this strategy will serve to improve the efficiency of  ...[more]

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