Ontology highlight
ABSTRACT:
SUBMITTER: Clay N
PROVIDER: S-EPMC3872536 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Clay Nicholas N Baek Kwanghyun K Shkumatov Artem A Lai Mei-Hsiu MH Smith Cartney E CE Rich Max M Kong Hyunjoon H
ACS applied materials & interfaces 20131001 20
This study presents a strategy to enhance the uptake of superparamagnetic iron oxide nanoparticle (SPIO) clusters by manipulating the cellular mechanical environment. Specifically, stem cells exposed to an orbital flow ingested almost a 2-fold greater amount of SPIO clusters than those cultured statically. Improvements in magnetic resonance (MR) contrast were subsequently achieved for labeled cells in collagen gels and a mouse model. Overall, this strategy will serve to improve the efficiency of ...[more]