Influence of cochleostomy and cochlear implant insertion on drug gradients following intratympanic application in Guinea pigs.
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ABSTRACT:
SUBMITTER: King EB
PROVIDER: S-EPMC3872819 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
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Influence of cochleostomy and cochlear implant insertion on drug gradients following intratympanic application in Guinea pigs.
King E B EB Hartsock J J JJ O'Leary S J SJ Salt A N AN
Audiology & neuro-otology 20130905 5
Locally applied drugs can protect residual hearing following cochlear implantation. The influence of cochlear implantation on drug levels in the scala tympani (ST) after round window application was investigated in guinea pigs using the marker trimethylphenylammonium (TMPA) measured in real time with TMPA-selective microelectrodes. TMPA concentration in the upper basal turn of the ST rapidly increased during implantation and then declined due to cerebrospinal fluid entering the ST at the cochlea ...[more]
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