Ontology highlight
ABSTRACT:
SUBMITTER: Xaver M
PROVIDER: S-EPMC3873250 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Xaver Martin M Huang Lingzhi L Chen Doris D Klein Franz F
PLoS genetics 20131226 12
Repairing broken chromosomes via joint molecule (JM) intermediates is hazardous and therefore strictly controlled in most organisms. Also in budding yeast meiosis, where production of enough crossovers via JMs is imperative, only a subset of DNA breaks are repaired via JMs, closely regulated by the ZMM pathway. The other breaks are repaired to non-crossovers, avoiding JM formation, through pathways that require the BLM/Sgs1 helicase. "Rogue" JMs that escape the ZMM pathway and BLM/Sgs1 are elimi ...[more]