Ontology highlight
ABSTRACT:
SUBMITTER: Vincenten N
PROVIDER: S-EPMC4749563 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Vincenten Nadine N Kuhl Lisa-Marie LM Lam Isabel I Oke Ashwini A Kerr Alastair Rw AR Hochwagen Andreas A Fung Jennifer J Keeney Scott S Vader Gerben G Marston Adèle L AL
eLife 20151214
During meiosis, crossover recombination is essential to link homologous chromosomes and drive faithful chromosome segregation. Crossover recombination is non-random across the genome, and centromere-proximal crossovers are associated with an increased risk of aneuploidy, including Trisomy 21 in humans. Here, we identify the conserved Ctf19/CCAN kinetochore sub-complex as a major factor that minimizes potentially deleterious centromere-proximal crossovers in budding yeast. We uncover multi-layere ...[more]