Ontology highlight
ABSTRACT:
SUBMITTER: Cheng X
PROVIDER: S-EPMC3873486 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Cheng Xin X He Ping P Lee Taehee T Yao Hailan H Li Rena R Shen Yong Y
The American journal of pathology 20140101 1
We recently discovered elevated β-secretase 1 (BACE1) activity in brains with sporadic Alzheimer disease (AD). Moreover, we also found high levels of BACE1 enzymatic activity in the cerebrospinal fluid from patients with both mild cognitive impairment (MCI) and AD. These results suggest that elevation of BACE1 enzymatic activity may occur early or may contribute to AD. We therefore examined whether BACE1 enzymatic activity was changed in MCI brains. BACE1 activity and tumor necrosis factor (TNF) ...[more]