Ontology highlight
ABSTRACT:
SUBMITTER: Newnham L
PROVIDER: S-EPMC3873974 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Newnham Louise L Jordan Philip W PW Carballo Jesus A JA Newcombe Sonya S Hoffmann Eva E
PloS one 20131227 12
Cells coordinate spindle formation with DNA repair and morphological modifications to chromosomes prior to their segregation to prevent cell division with damaged chromosomes. Here we uncover a novel and unexpected role for Aurora kinase in preventing the formation of spindles by Clb5-CDK (S-CDK) during meiotic prophase I and when the DDR is active in budding yeast. This is critical since S-CDK is essential for replication during premeiotic S-phase as well as double-strand break induction that f ...[more]