Ontology highlight
ABSTRACT:
SUBMITTER: Carvalhal S
PROVIDER: S-EPMC4591688 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Carvalhal Sara S Ribeiro Susana Abreu SA Arocena Miguel M Kasciukovic Taciana T Temme Achim A Koehler Katrin K Huebner Angela A Griffis Eric R ER
Molecular biology of the cell 20150805 19
The formation of the mitotic spindle is a complex process that requires massive cellular reorganization. Regulation by mitotic kinases controls this entire process. One of these mitotic controllers is Aurora A kinase, which is itself highly regulated. In this study, we show that the nuclear pore protein ALADIN is a novel spatial regulator of Aurora A. Without ALADIN, Aurora A spreads from centrosomes onto spindle microtubules, which affects the distribution of a subset of microtubule regulators ...[more]