Ontology highlight
ABSTRACT:
SUBMITTER: Cong R
PROVIDER: S-EPMC3874179 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Cong Rong R Das Sadhan S Douet Julien J Wong Jiemin J Buschbeck Marcus M Mongelard Fabien F Bouvet Philippe P
Nucleic acids research 20130925 1
The regulation of ribosomal DNA transcription is an important step for the control of cell growth. Epigenetic marks such as DNA methylation and posttranslational modifications of canonical histones have been involved in this regulation, but much less is known about the role of histone variants. In this work, we show that the histone variant macroH2A1 is present on the promoter of methylated rDNA genes. The inhibition of the expression of macroH2A1 in human HeLa and HepG2 cells and in a mouse ES ...[more]