Ontology highlight
ABSTRACT:
SUBMITTER: Nechooshtan G
PROVIDER: S-EPMC3874183 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Nechooshtan Gal G Elgrably-Weiss Maya M Altuvia Shoshy S
Nucleic acids research 20130926 1
Previously, we described a novel pH-responsive RNA element in Escherichia coli that resides in the 5' untranslated region of the alx gene and controls its translation in a pH-dependent manner. Under normal growth conditions, this RNA region forms a translationally inactive structure, but when transcribed under alkaline conditions, it forms an active structure producing the Alx protein. We identified two distinct transcriptional pause sites and proposed that pausing at these sites interfered with ...[more]