Ontology highlight
ABSTRACT:
SUBMITTER: Widom JR
PROVIDER: S-EPMC6565381 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Molecular cell 20181101 3
Numerous classes of riboswitches have been found to regulate bacterial gene expression in response to physiological cues, offering new paths to antibacterial drugs. As common studies of isolated riboswitches lack the functional context of the transcription machinery, we here combine single-molecule, biochemical, and simulation approaches to investigate the coupling between co-transcriptional folding of the pseudoknot-structured preQ<sub>1</sub> riboswitch and RNA polymerase (RNAP) pausing. We sh ...[more]