Ontology highlight
ABSTRACT:
SUBMITTER: Dajas-Bailador F
PROVIDER: S-EPMC3874787 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Dajas-Bailador Federico F Bantounas Ioannis I Jones Emma V EV Whitmarsh Alan J AJ
Journal of cell science 20131106 Pt 1
The polarisation of developing neurons to form axons and dendrites is required for the establishment of neuronal connections leading to proper brain function. The protein kinase AKT and the MAP kinase scaffold protein JNK-interacting protein-1 (JIP1) are important regulators of axon formation. Here we report that JIP1 and AKT colocalise in axonal growth cones of cortical neurons and collaborate to promote axon growth. The loss of AKT protein from the growth cone results in the degradation of JIP ...[more]