RNA interference functions as an antiviral immunity mechanism in mammals.
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ABSTRACT:
SUBMITTER: Li Y
PROVIDER: S-EPMC3875315 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Publications
RNA interference functions as an antiviral immunity mechanism in mammals.
Li Yang Y Lu Jinfeng J Han Yanhong Y Fan Xiaoxu X Ding Shou-Wei SW
Science (New York, N.Y.) 20131001 6155
Diverse eukaryotic hosts produce virus-derived small interfering RNAs (siRNAs) to direct antiviral immunity by RNA interference (RNAi). However, it remains unknown whether the mammalian RNAi pathway has a natural antiviral function. Here, we show that infection of hamster cells and suckling mice by Nodamura virus (NoV), a mosquito-transmissible RNA virus, requires RNAi suppression by its B2 protein. Loss of B2 expression or its suppressor activity leads to abundant production of viral siRNAs and ...[more]
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