Ontology highlight
ABSTRACT:
SUBMITTER: Luthra P
PROVIDER: S-EPMC3875338 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Cell host & microbe 20130701 1
The cytoplasmic pattern recognition receptor RIG-I is activated by viral RNA and induces type I IFN responses to control viral replication. The cellular dsRNA binding protein PACT can also activate RIG-I. To counteract innate antiviral responses, some viruses, including Ebola virus (EBOV), encode proteins that antagonize RIG-I signaling. Here, we show that EBOV VP35 inhibits PACT-induced RIG-I ATPase activity in a dose-dependent manner. The interaction of PACT with RIG-I is disrupted by wild-typ ...[more]