FOXO transcription factors throughout T cell biology.
Ontology highlight
ABSTRACT:
SUBMITTER: Hedrick SM
PROVIDER: S-EPMC3875397 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Publications
FOXO transcription factors throughout T cell biology.
Hedrick Stephen M SM Hess Michelini Rodrigo R Doedens Andrew L AL Goldrath Ananda W AW Stone Erica L EL
Nature reviews. Immunology 20120901 9
The outcome of an infection with any given pathogen varies according to the dosage and route of infection, but, in addition, the physiological state of the host can determine the efficacy of clearance, the severity of infection and the extent of immunopathology. Here we propose that the forkhead box O (FOXO) transcription factor family--which is central to the integration of growth factor signalling, oxidative stress and inflammation--provides connections between physical well-being and the form ...[more]
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