Ontology highlight
ABSTRACT:
SUBMITTER: Farhan M
PROVIDER: S-EPMC7407656 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Farhan Mohd M Silva Marta M Xingan Xing X Huang Yu Y Zheng Wenhua W
Cells 20200630 7
Forkhead box O transcription factors (FOXOs) regulate several signaling pathways and play crucial roles in health and disease. FOXOs are key regulators of the expression of genes involved in multiple cellular processes and their deregulation has been implicated in cancer. FOXOs are generally considered tumor suppressors and evidence also suggests that they may have a role in the regulation of cancer metabolism and angiogenesis. In order to continue growing and proliferating, tumor cells have to ...[more]