Ontology highlight
ABSTRACT:
SUBMITTER: Zalmas LP
PROVIDER: S-EPMC3875678 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Zalmas Lykourgos-Panagiotis LP Coutts Amanda S AS Helleday Thomas T La Thangue Nicholas B NB
Cell cycle (Georgetown, Tex.) 20130820 18
The cellular response to DNA damage, mediated by the DNA repair process, is essential in maintaining the integrity and stability of the genome. E2F-7 is an atypical member of the E2F family with a role in negatively regulating transcription and cell cycle progression under DNA damage. Surprisingly, we found that E2F-7 makes a transcription-independent contribution to the DNA repair process, which involves E2F-7 locating to and binding damaged DNA. Further, E2F-7 recruits CtBP and HDAC to the dam ...[more]