Ontology highlight
ABSTRACT:
SUBMITTER: Melancon BJ
PROVIDER: S-EPMC3876030 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Melancon Bruce J BJ Tarr James C JC Panarese Joseph D JD Wood Michael R MR Lindsley Craig W CW
Drug discovery today 20130917 23-24
Allosteric modulation of AMPA, NR2B, mGlu2, mGlu5 and M1, targeting glutamatergic dysfunction, represents a significant area of research for the treatment of schizophrenia. Of these targets, clinical promise has been demonstrated using muscarinic activators for the treatment of Alzheimer's disease (AD) and schizophrenia. These diseases have inspired researchers to determine the effects of modulating cholinergic transmission in the forebrain, which is primarily regulated by one of five subtypes o ...[more]