Flavonoids with M1 muscarinic acetylcholine receptor binding activity.
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ABSTRACT:
SUBMITTER: Swaminathan M
PROVIDER: S-EPMC6270666 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Publications
Flavonoids with M1 muscarinic acetylcholine receptor binding activity.
Swaminathan Meyyammai M Chee Chin Fei CF Chin Sek Peng SP Buckle Michael J C MJ Rahman Noorsaadah Abd NA Doughty Stephen W SW Chung Lip Yong LY
Molecules (Basel, Switzerland) 20140627 7
Muscarinic acetylcholine receptor-active compounds have potential for the treatment of Alzheimer's disease. In this study, a series of natural and synthetic flavones and flavonols was assayed in vitro for their ability to inhibit radioligand binding at human cloned M1 muscarinic receptors. Several compounds were found to possess competitive binding affinity (Ki=40-110 µM), comparable to that of acetylcholine (Ki=59 µM). Despite the fact that these compounds lack a positively-charged ammonium gro ...[more]
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