Ontology highlight
ABSTRACT:
SUBMITTER: Li T
PROVIDER: S-EPMC3876934 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Li Tuo T Chen Jin J Cristea Ileana M IM
Cell host & microbe 20131101 5
Nuclear sensing of viral DNA has emerged as an essential step in innate immune responses against herpesviruses. Here, we provide mechanistic insight into host recognition of human cytomegalovirus (HCMV) and subsequent immune evasion by this prominent DNA virus. We establish that the interferon-inducible protein IFI16 acts as a nuclear DNA sensor following HCMV infection, binding viral DNA and triggering expression of antiviral cytokines via the STING-TBK1-IRF3 signaling pathway. The HCMV tegumen ...[more]