Ontology highlight
ABSTRACT:
SUBMITTER: Strazic Geljic I
PROVIDER: S-EPMC6957316 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
eLife 20200113
Cytomegaloviruses (CMVs) are ubiquitous pathogens known to employ numerous immunoevasive strategies that significantly impair the ability of the immune system to eliminate the infected cells. Here, we report that the single mouse CMV (MCMV) protein, m154, downregulates multiple surface molecules involved in the activation and costimulation of the immune cells. We demonstrate that m154 uses its cytoplasmic tail motif, DD, to interfere with the adaptor protein-1 (AP-1) complex, implicated in intra ...[more]