Ontology highlight
ABSTRACT:
SUBMITTER: Wright JH
PROVIDER: S-EPMC3876966 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Wright Jocelyn H JH Johnson Melissa M MM Shimizu-Albergine Masami M Bauer Renay L RL Hayes Brian J BJ Surapisitchat James J Hudkins Kelly L KL Riehle Kimberly J KJ Johnson Simon C SC Yeh Matthew M MM Bammler Theodor K TK Beyer Richard P RP Gilbertson Debra G DG Alpers Charles E CE Fausto Nelson N Campbell Jean S JS
International journal of cancer 20130916 4
Cirrhosis is the primary risk factor for the development of hepatocellular carcinoma (HCC), yet the mechanisms by which cirrhosis predisposes to carcinogenesis are poorly understood. Using a mouse model that recapitulates many aspects of the pathophysiology of human liver disease, we explored the mechanisms by which changes in the liver microenvironment induce dysplasia and HCC. Hepatic expression of platelet-derived growth factor C (PDGF-C) induces progressive fibrosis, chronic inflammation, ne ...[more]